Does ‘natural Ozempic’ really exist?

We’ve all seen the effects of GLP-1 agonist medications, or GLP-1s. The weight some people strive to lose seemingly fades away when aided by the prescription medications.

Commonly called Ozempic — the brand name of a GLP-1 medication approved only to treat Type 2 diabetes — GLP-1 medications have been used to successfully support weight loss for millions of people.

GLP-1s specifically approved for weight loss include Wegovy, Saxenda and Zepbound, and their weight loss effectiveness is often lauded. However, the medications can be costly if not covered by a person’s insurance provider.

Thus, a question has flooded social media: When taken together, can certain over-the-counter supplements mimic the weight loss effect of a GLP-1?

A doctor weighs in

According to some social media influencers, a combination of natural supplements can provide the same results as Ozempic without the unpleasant side effects, such as nausea, diarrhea and constipation. The supposed weight loss “cocktail” of supplements includes magnesium, ashwagandha, L-theanine, myo-inositol and D-chiro inositol, berberine, and vitamins D3 and K2.

However, Dr. Neelima Chu, an endocrinologist with Sharp Rees-Stealy Medical Group, says that while these supplements may have benefits, they’re ineffective for weight loss. Here, she shares the actual benefits of each:

“While the supplements above have demonstrated benefits for stress reduction, improved sleep and enhanced insulin sensitivity, they do not replicate the powerful weight loss effects seen with GLP-1 receptor agonists,” Dr. Chu says.

What’s the difference?

GLP-1s work by suppressing appetite, slowing gastric emptying and improving insulin function, Dr. Chu Explains. Those who take GLP-1s typically lose between 10% and 20% of their body weight, while those taking a supplement combination are unlikely to lose a measurable amount unless accompanied by increased exercise and a restrictive diet.

However, unlike GLP-1s, Dr. Chu says that the supplement combination shouldn’t have significant side effects. Although, diarrhea may occur if supplements like magnesium or berberine are taken at a higher dosage than the recommended amount.

“It’s essential to discuss any supplements you are taking, or plan to take, with your doctor to avoid harmful interactions,” says Dr. Chu. “For instance, people with high levels of calcium in their blood should talk with their doctor before taking high doses of vitamin D or K. What’s more, your doctor can help you identify safe and effective weight loss methods if needed.”

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